If you're one of the 284 million people worldwide dealing with anxiety right now, and you're tired of feeling like panic is controlling your life, this comprehensive guide could change everything. Recent research from 2025 reveals natural anxiety remedies that researchers are calling "game-changers" - and the best part? You can start using them today from the comfort of your own home.

Anxiety affects over 40 million adults in the US alone, and traditional treatments don't work for everyone. The challenges are real - you've probably scrolled through countless articles promising "quick fixes" that didn't work, or you're concerned about the side effects of prescription medications. But here's what's exciting: new research from 2025 shows that certain natural remedies can reduce anxiety symptoms by up to 50% when used correctly.

Today, we're breaking down the exact protocols that are working for thousands of people, backed by peer-reviewed studies and clinical trials. By the end of this article, you'll have a complete toolkit of natural anxiety remedies - from specific essential oils that activate your brain's calm response in under 60 seconds, to exact herbal teas that can help you sleep better tonight, plus the one vitamin deficiency that could be making your anxiety worse and how to fix it naturally.

The Science Behind Natural Anxiety Relief

Before we dive into the remedies, let's talk about why natural approaches are gaining so much attention. A 2025 meta-analysis published in BMC Medical Education found that 43% of people with anxiety are actively seeking alternatives to pharmaceutical drugs, and they're finding real results.

Your brain's anxiety response involves complex pathways including the GABAergic system, your hypothalamic-pituitary-adrenal axis, and neurotransmitters like serotonin. The natural remedies we're covering today work by gently modulating these same pathways, but without the harsh side effects associated with conventional medications.

Everything shared here is backed by recent clinical trials, systematic reviews, and meta-analyses. We're not talking about old wives' tales - this is legitimate science that's changing how we approach anxiety treatment in 2025.

Essential Oils and Aromatherapy for Instant Anxiety Relief

Let's start with something that can work in under 60 seconds - aromatherapy. Recent research shows that certain essential oils can activate your brain's calm response faster than almost any other natural method.

A 2025 network meta-analysis of essential oils for anxiety found that citrus aurantium essential oil (bitter orange) was the most effective for reducing both state and trait anxiety. However, let's focus on the oils you can easily find and use effectively:

Lavender Oil (Lavandula angustifolia)

Lavender contains linalool and linalyl acetate that directly interact with your GABA receptors - the same system targeted by anti-anxiety medications. A groundbreaking 2025 study on brain surgery patients showed anxiety scores dropped by nearly 50% after 7 nights of lavender aromatherapy. The patients experienced measurable improvements in sleep quality and significant reductions in cortisol levels.

How to use: Add 3-4 drops to a diffuser, or dilute 2 drops in a carrier oil for topical application on wrists and temples. For acute anxiety, try combining lavender inhalation with the 4-7-8 breathing technique.

Bergamot Orange Oil

Clinical research from 2020 found bergamot oil significantly reduced pre-surgical anxiety in hospital patients. The oil contains compounds that help regulate cortisol levels and modulate your stress response. Multiple studies confirm its effectiveness for both acute and chronic anxiety management.

How to use: Diffuse during stressful times, or apply topically with carrier oil. Important note: avoid sun exposure after topical use, as bergamot can increase photosensitivity.

Chamomile Oil

Contains apigenin, which binds to the same brain receptors as anti-anxiety medications but in a milder, non-habit-forming way. This makes chamomile oil perfect for evening relaxation and sleep preparation, offering a natural transition from day stress to nighttime calm.

Practical Aromatherapy Protocol

For acute anxiety episodes, try this evidence-based protocol: Use the 4-7-8 breathing technique while inhaling lavender oil. Breathe in for 4 counts, hold for 7, exhale for 8, all while experiencing the calming scent. This combines two anxiety-fighting mechanisms - controlled breathing and aromatherapy - for maximum effectiveness.

Herbal Teas and Adaptogens That Actually Work

If you prefer something you can sip and savor, let's explore herbal teas and adaptogens. These aren't just trendy wellness drinks - they're powerful natural medicines with serious research backing their anxiety-fighting properties.

Chamomile Tea: The Gentle Giant

German chamomile contains the highest concentration of apigenin, a flavonoid that produces anxiolytic effects through GABA receptor modulation. A 2024 systematic review of 10 clinical trials found that 9 studies concluded chamomile is effective in reducing anxiety symptoms.

The landmark University of Pennsylvania study demonstrated that pharmaceutical-grade chamomile extract (standardized to 1.2% apigenin) significantly reduced anxiety symptoms in patients with generalized anxiety disorder. Long-term studies show continued benefits for up to 26 weeks, with participants maintaining significantly lower anxiety scores compared to placebo groups.

Clinical Protocol: Drink 1-2 strong cups 30-60 minutes before stressful events. For therapeutic effects, steep 2-3 tea bags or 2 tablespoons of loose herbs per cup for 10-15 minutes. Think of this as herbal medicine, not just a pleasant beverage.

Ashwagandha: The Stress-Fighting Adaptogen

This ancient Ayurvedic herb has gained modern scientific validation for its remarkable ability to combat anxiety and stress. Recent clinical trials show ashwagandha can reduce cortisol levels by up to 30% and significantly improve anxiety scores on validated clinical scales.

A 2025 meta-analysis of 15 studies with 873 participants found that ashwagandha supplementation significantly reduced anxiety according to the Hamilton Anxiety Rating Scale, with effects becoming pronounced after 8 weeks of treatment. The herb works by modulating your hypothalamic-pituitary-adrenal (HPA) axis - your body's primary stress response system.

Dosage and Usage: Studies show optimal results with 300-600mg daily of standardized root extract. Available as tea, powder (mixed with warm milk), or capsules. Start with lower doses and consult your healthcare provider, especially if you have existing medical conditions.

Lemon Balm Tea: The Calming Mint

Member of the mint family with natural anxiolytic properties, lemon balm increases GABA activity in the brain while promoting relaxation. Research shows it's particularly effective for evening anxiety and sleep issues, making it an excellent choice for nighttime routines.

Usage: Can be combined with chamomile for enhanced calming effects. Steep for 10-15 minutes to extract maximum beneficial compounds.

Passionflower: Nature's Anxiolytic

Clinical trials demonstrate that passionflower is as effective as some prescription medications for anxiety relief. It works by naturally increasing GABA levels in the brain, making it particularly effective for racing thoughts and mental restlessness.

Pro Tip for Maximum Effectiveness: Most people don't steep herbal teas long enough or use enough herb for therapeutic effects. For anxiety relief, you want a strong brew. Use 2-3 tea bags or 2 tablespoons of loose herbs per cup, and steep for at least 10-15 minutes. The goal is creating herbal medicine, not just a pleasant drink.

Saffron - The Golden Spice for Anxiety Relief

Now let's discuss something truly remarkable - saffron, often called "red gold." Recent clinical research has revealed that this precious spice is actually as effective as prescription medications for anxiety, but with a superior safety profile.

Groundbreaking Clinical Evidence

A 2025 meta-analysis comparing saffron directly to SSRIs found no significant difference in anxiety reduction, establishing what researchers call "therapeutic equivalence." This means saffron works just as well as conventional anxiety medications, but with 6% fewer side effects.

Multiple head-to-head clinical trials support these findings. One study found that 30mg of saffron daily was equivalent to 40mg of citalopram for anxiety reduction, but with fewer side effects like dizziness and stomach upset. Another clinical trial showed that adding saffron to existing anxiety treatment enhanced results significantly.

The Science Behind Saffron's Effectiveness

Saffron contains three key bioactive compounds that work synergistically to calm anxiety:

Crocin acts as a positive allosteric modulator at GABA-benzodiazepine receptor complexes - the same system targeted by anti-anxiety medications, but without the risk of dependency.

Crocetin functions as a high-affinity NMDA receptor antagonist with excellent blood-brain barrier penetration, reaching therapeutic levels within 30 minutes of consumption.

Safranal modulates both GABAergic and opioidergic systems, providing comprehensive anxiety relief through multiple pathways. Other research suggests that saffron may help cut down on food cravings, a nice "side" effect.

Clinical Dosage and Timeline

The optimal dose established through clinical trials is 28-30mg daily of standardized saffron extract. Look for products standardized to 3-6% total crocins and 0.2-0.35% safranal for maximum therapeutic benefit.

Treatment Timeline: Benefits typically emerge within 2-4 weeks, with peak therapeutic effects achieved between 6-8 weeks. Long-term studies demonstrate safety for up to 26 weeks of continuous use.

Exceptional Safety Profile

Saffron has an outstanding safety record in clinical trials. Unlike benzodiazepines, there's no risk of dependency, tolerance, or withdrawal syndrome. The main contraindications are pregnancy (first trimester) and bleeding disorders. Common side effects affect less than 5% of users and include mild gastrointestinal upset.

Vitamins and Supplements for Long-Term Anxiety Management

Here's something that might surprise you - that persistent anxiety you're experiencing could actually be your body signaling specific nutrient deficiencies. Let's examine the vitamin and mineral deficiencies directly linked to anxiety symptoms and how to address them effectively.

Magnesium: The 'Relaxation Mineral'

Research indicates that up to 68% of Americans are magnesium deficient, and this deficiency is directly correlated with increased anxiety symptoms. Magnesium regulates your nervous system and muscle function, with deficiency symptoms including anxiety, muscle tension, and sleep problems.

A landmark 2017 clinical trial published in PLOS One found that 248mg of elemental magnesium daily for 6 weeks improved depression scores by 6 points and anxiety by over 4 points. The effects were observed within two weeks and occurred across diverse populations regardless of age, gender, or baseline severity.

Best Forms and Dosage: Magnesium glycinate or magnesium threonate offer superior bioavailability for brain health. Recommended dosage: 200-400mg daily, preferably taken before bed to support both anxiety relief and sleep quality.

Vitamin D: The 'Sunshine Vitamin'

Low vitamin D levels are directly correlated with increased anxiety and depression in multiple large-scale studies. Most people require 2000-4000 IU daily, especially during winter months when sun exposure is limited.

Clinical Recommendation: Get tested to determine your baseline levels. Optimal levels should be 50-80 ng/mL for mental health benefits. Combine with vitamin K2 for better absorption and utilization.

B-Complex Vitamins: The Stress Fighters

B6, B12, and folate are crucial for neurotransmitter production, and stress rapidly depletes these essential nutrients. Clinical research shows that B-vitamin deficiency can exacerbate anxiety symptoms, while supplementation supports healthy nervous system function.

Best Approach: Look for methylated forms (methylcobalamin, methylfolate) for superior absorption. This is particularly important for vegetarians and vegans who are at higher risk for B12 deficiency.

Omega-3 Fatty Acids: Brain Anti-Inflammatories

EPA and DHA reduce neuroinflammation and support healthy brain function. Studies demonstrate that 1000-2000mg daily can significantly reduce anxiety symptoms by addressing underlying inflammatory processes.

Quality Matters: Choose high-quality fish oil or algae-based supplements that are third-party tested to avoid mercury contamination.

Implementation Strategy

Start with magnesium and vitamin D testing - these are the two most common deficiencies linked to anxiety. Add them to your routine first, then consider B-complex and omega-3s after 4-6 weeks. Remember, supplements work best as part of a comprehensive approach, not as isolated interventions.

Breathing Techniques and Mindfulness Practices

Now let's explore the most underrated anxiety tool that costs absolutely nothing and works instantly - your breath. Proper breathing techniques can literally rewire your nervous system in real-time, activating your body's natural relaxation response.

The 4-7-8 Technique (Dr. Andrew Weil's Method)

This scientifically-validated technique activates your parasympathetic nervous system within minutes:

• Inhale through nose for 4 counts
• Hold breath for 7 counts
• Exhale through mouth for 8 counts
• Repeat 4 cycles, 2-3 times daily

Research shows this technique can reduce anxiety symptoms immediately and provides cumulative benefits with regular practice.

Box Breathing (Navy SEAL Technique)

Used by elite military units for stress management under extreme conditions:

• Inhale for 4, hold for 4, exhale for 4, hold for 4
• Perfect for acute anxiety and panic attacks
• Can be performed anywhere, anytime
• Provides immediate nervous system regulation

Belly Breathing for Vagus Nerve Activation

This technique specifically targets your vagus nerve - your body's primary "rest and digest" pathway:

• Place one hand on chest, one on belly
• Breathe so only the bottom hand moves
• Activates vagus nerve stimulation
• Practice 5-10 minutes daily for long-term benefits

Mindfulness Integration: The 5-4-3-2-1 Grounding Technique

Combine breathing exercises with this evidence-based grounding method:

• Name 5 things you can see
• 4 things you can touch
• 3 things you can hear
• 2 things you can smell
• 1 thing you can taste

This technique anchors you in the present moment while controlled breathing calms your nervous system, providing comprehensive anxiety relief.

Lifestyle Changes and Home Remedies for Daily Anxiety Management

Finally, let's examine the lifestyle modifications that can transform your relationship with anxiety from the inside out. These aren't quick fixes - they're foundation builders that create lasting resilience against stress and anxiety.

Exercise: Nature's Antidepressant

Even 20 minutes of walking can reduce anxiety for up to 12 hours according to recent studies. High-intensity exercise may be more effective than low-intensity activities for anxiety relief, as it releases endorphins and reduces stress hormones naturally.

The 'Anxiety Walk' Protocol: When you feel overwhelmed, take a 10-minute walk outside. The combination of movement, fresh air, and natural light provides multiple anxiety-reducing benefits simultaneously.

Sleep Hygiene for Anxiety Management

Poor sleep increases anxiety by up to 30% the next day, creating a vicious cycle. Research-backed sleep strategies include:

• Create a consistent wind-down routine with chamomile tea and lavender aromatherapy
• Keep your bedroom cool (65-68°F) and completely dark
• Avoid screens 1 hour before bed - blue light disrupts melatonin production
• Use magnesium supplementation to support both sleep quality and anxiety reduction

Nutrition for Calm

Your diet directly impacts your anxiety levels through multiple mechanisms:

Reduce caffeine after 2 PM - it can trigger anxiety symptoms 6-8 hours after consumption. Include probiotic foods - your gut produces 90% of your body's serotonin. Choose anti-inflammatory foods: fatty fish, leafy greens, berries, and nuts. Stabilize blood sugar by eating protein with every meal to prevent anxiety-triggering glucose spikes.

Environmental Modifications

Your physical environment significantly impacts your mental state:

• Declutter your space - visual chaos increases cortisol production
• Add plants to your home - they naturally purify air and reduce stress hormones
• Create a designated 'calm corner' with soft lighting and relaxing scents
• Limit news consumption - constant negative information feeds anxiety and stress

Integration Strategy for Lasting Results

Don't try to implement everything at once - that approach creates more stress. Pick ONE change from each category and implement them gradually. Master one technique completely before adding another. Small, consistent actions create massive results over time.

Your Action Plan for Natural Anxiety Relief

Let's recap your comprehensive natural anxiety toolkit: Essential oils like lavender and bergamot for immediate relief, herbal teas and adaptogens for daily support, saffron for pharmaceutical-grade efficacy, targeted vitamins to address nutritional deficiencies, breathing techniques for instant calm, and lifestyle changes for long-term resilience.

Start Today With One Simple Step

Here's your immediate action plan: Choose ONE technique from this guide and implement it today. Maybe it's trying the 4-7-8 breathing technique right now, ordering chamomile tea for tonight, or scheduling a vitamin D test. Small, consistent actions compound into transformative results.

Building Your Personal Protocol

After mastering your first technique, gradually add complementary approaches. For example, start with morning breathing exercises, add evening chamomile tea, then incorporate magnesium supplementation. This layered approach creates comprehensive anxiety management without overwhelming your system.

The Science of Hope

Remember, you're not alone in this journey. Millions of people are finding real relief with these evidence-based natural approaches. The research is clear: your anxiety doesn't define you, and with the right tools and consistent application, you can absolutely reclaim your peace of mind and build lasting resilience against stress.

Your healing journey begins with that first small step. The tools are here, the science supports them, and your brighter, calmer future is waiting. Take that step today - you've got this.

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This article is based on peer-reviewed research and clinical studies. Always consult with healthcare professionals before making significant changes to your anxiety management approach, especially if you're currently taking medications or have underlying health conditions.

References

1. Ghaderi A, Banafshe HR, Motmaen M, et al: Clinical and metabolic response to vitamin D plus probiotic in schizophrenia patients. BMC Psychiatry 2019; 19:77
2. Boyle NB, Lawton C, Dye L: The effects of magnesium supplementation on subjective anxiety and stress—a systematic review. Nutrients 2017; 9:429
3. Tarleton EK, Littenberg B, MacLean CD, et al: Role of magnesium supplementation in the treatment of depression: a randomized clinical trial. PLoS One 2017; 12:e0180067
4. Salve J, Pate S, Debnath K, et al: Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study. Cureus 2019; 11:e6466
5. Chandrasekhar K, Kapoor J, Anishetty S: A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med 2012; 34:255-262
6. Lopresti AL, Smith SJ, Metse AP, et al: A randomized, double-blind, placebo-controlled trial investigating the effects of an Ocimum tenuiflorum (Holy Basil) extract on stress, mood, and sleep in adults experiencing stress. Front Nutr 2022; 9:965130
7. Majeed M, Nagabhushanam K, Murali A, et al: A standardized Withania somnifera (Linn.) root extract with piperine alleviates the symptoms of anxiety and depression by increasing serotonin levels: a double-blind, randomized, placebo-controlled study. J Integr Complement Med 2024; 30:459-468
8. Akhgarjand C, Bagheri A, Amirani E, et al: Does ashwagandha supplementation have a beneficial effect on the management of anxiety and stress? A systematic review and meta-analysis of randomized controlled trials. Phytother Res 2022; 36:4115-4124
9. Amsterdam JD, Li Y, Soeller I, et al: A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. J Clin Psychopharmacol 2009; 29:378-382
10. Mao JJ, Xie SX, Keefe JR, et al: Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: a randomized clinical trial. Phytomedicine 2016; 23:1735-1742
11. Zaccara S, Panfili G, Benvenuto A: The effect of oral chamomile on anxiety: a systematic review of clinical trials. Clin Nutr Res 2024; 13:139-154
12. Viola H, Wasowski C, Levi de Stein M, et al: Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med 1995; 61:213-216
13. Avallone R, Zanoli P, Puia G, et al: Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochem Pharmacol 2000; 59:1387-1394
14. Shafiee M, Arekhi S, Omranzadeh A, et al: Effect of saffron versus selective serotonin reuptake inhibitors (SSRIs) in treatment of depression and anxiety: a meta-analysis of randomized controlled trials. Nutr Rev 2025; 83:e751
15. Ghajar A, Neishabouri SM, Velayati N, et al: Crocus sativus L. versus citalopram in the treatment of major depressive disorder with anxious distress: a double-blind, controlled clinical trial. Pharmacopsychiatry 2017; 50:152-160
16. Talaei A, Hassanpour Moghadam M, Sajadi Tabassi SA, et al: Crocin, the main active saffron constituent, as an adjunctive treatment in major depressive disorder: a randomized, double-blind, placebo-controlled, pilot clinical trial. J Affect Disord 2015; 174:51-56
17. Jackson PA, Forster J, Khan J, et al: Effects of saffron extract supplementation on mood, well-being, and response to a psychosocial stressor in healthy adults: a randomized, double-blind, parallel group, clinical trial. Front Nutr 2021; 7:606124
18. Lopresti AL, Smith SJ, Drummond PD: An examination into the effects of a saffron extract (affron) on mood and general wellbeing in adults experiencing low mood: a randomized, double-blind, placebo-controlled trial. J Nutr 2025; 155:503-516
19. Pitsikas N, Tarantilis PA: The GABAA-benzodiazepine receptor antagonist flumazenil abolishes the anxiolytic effects of the active constituents of Crocus sativus L. crocins in rats. Molecules 2020; 25:5797
20. Ahmad A, Raish M, Bin Jardan YA, et al: ADME/PK insights of crocetin: a molecule having an unusual chemical structure with druglike features. ACS Omega 2024; 9:25447-25459
21. Lopresti AL, Drummond PD: Saffron (Crocus sativus) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action. Hum Psychopharmacol 2014; 29:517-527
22. Khazdair MR, Boskabady MH, Hosseini M, et al: The effects of Crocus sativus (saffron) and its constituents on nervous system: a review. Avicenna J Phytomed 2015; 5:376-391
23. Bagur MJ, Salinas GL, Jiménez-Monreal AM, et al: Saffron: an old medicinal plant and a potential novel functional food. Molecules 2017; 23:30
24. Hosseini A, Razavi BM, Hosseinzadeh H: Saffron (Crocus sativus) petal as a new pharmacological target: a review. Iran J Basic Med Sci 2018; 21:1091-1099
25. Lopresti AL, Drummond PD, Inarejos-García AM, et al: affron, a standardised extract from saffron (Crocus sativus L.) for the treatment of youth anxiety and depressive symptoms: a randomised, double-blind, placebo-controlled study. J Affect Disord 2018; 232:349-357
26. Mazidi M, Shemshian M, Mousavi SH, et al: A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression. J Complement Integr Med 2016; 13:195-199
27. Rajizadeh A, Mozaffari-Khosravi H, Yassini-Ardakani M, et al: Effect of magnesium supplementation on depression status in depressed patients with magnesium deficiency: a randomized, double-blind, placebo-controlled trial. Nutrition 2017; 35:56-60
28. Mousain-Bosc M, Roche M, Polge A, et al: Improvement of neurobehavioral disorders in children supplemented with magnesium-vitamin B6. I. Attention deficit hyperactivity disorders. Magnes Res 2006; 19:46-52
29. Sartori SB, Whittle N, Hetzenauer A, et al: Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment. Neuropharmacology 2012; 62:304-312
30. Botturi A, Ciappolino V, Delvecchio G, et al: The role and the effect of magnesium in mental disorders: a systematic review. Nutrients 2020; 12:1661
31. Huang Y, Ruan S, Yang Y, et al: Impact of dietary magnesium intake on depression risk in American adults: a cross-sectional study of the National Health and Nutrition Examination Survey 2005–2020. Front Nutr 2025; 12:1484344
32. Weibel S, Rücker G, Eberhart LH, et al: Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis. Cochrane Database Syst Rev 2020; 10:CD012859
33. Boyle NB, Lawton CL, Allen R, et al: The effects of magnesium supplementation on subjective anxiety and stress—a systematic review. Nutrients 2017; 9:429
34. Fard FE, Mirghafourvand M, Mohammad-Alizadeh Charandabi S, et al: Effects of zinc and magnesium supplements on postpartum depression and anxiety: a randomized controlled clinical trial. Women Health 2017; 57:1115-1128
35. Serefko A, Szopa A, Poleszak E: Magnesium and depression. Magnes Res 2016; 29:112-119
36. Slutsky I, Abumaria N, Wu LJ, et al: Enhancement of learning and memory by elevating brain magnesium. Neuron 2010; 65:165-177
37. Mikkelsen K, Stojanovska L, Prakash M, et al: The effects of vitamin B on the immune/cytokine network and their involvement in depression. Maturitas 2017; 96:58-71
38. Skarupski KA, Tangney C, Li H, et al: Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time. Am J Clin Nutr 2010; 92:330-335
39. Freeman MP, Hibbeln JR, Wisner KL, et al: Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry. J Clin Psychiatry 2010; 71:1397-1409
40. Sublette ME, Ellis SP, Geant AL, et al: Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression. J Clin Psychiatry 2011; 72:1577-1584
41. Guu TW, Mischoulon D, Sarris J, et al: International Society for Nutritional Psychiatry Research practice guidelines for omega-3 fatty acids in the treatment of major depressive disorder. Psychother Psychosom 2019; 88:263-273
42. Anglin RE, Samaan Z, Walter SD, et al: Vitamin D deficiency and depression in adults: systematic review and meta-analysis. Br J Psychiatry 2013; 202:100-107
43. Menon V, Kar SK, Suthar N, et al: Vitamin D and depression: a critical appraisal of the evidence and future directions. Indian J Psychol Med 2020; 42:11-21
44. Ju SY, Lee YJ, Jeong SN: Serum 25-hydroxyvitamin D levels and the risk of depression: a systematic review and meta-analysis. J Nutr Health Aging 2013; 17:447-455
45. Weil A: Breathing: The Master Key to Self Healing. Louisville, CO, Sounds True, 1999
46. Elbers J, McCraty R: HeartMath interventions in children. Appl Psychol Health Well Being 2020; 12:1203-1232
47. Jerath R, Edry JW, Barnes VA, et al: Physiology of long pranayamic breathing: neural respiratory elements may provide a mechanism that explains how slow deep breathing shifts the autonomic nervous system. Med Hypotheses 2006; 67:566-571
48. Brown RP, Gerbarg PL: Sudarshan Kriya yogic breathing in the treatment of stress, anxiety, and depression: part I—neurophysiologic model. J Altern Complement Med 2005; 11:189-201
49. Ma X, Yue ZQ, Gong ZQ, et al: The effect of diaphragmatic breathing on attention, negative affect and stress in healthy adults. Front Psychol 2017; 8:874
50. Zaccaro A, Piarulli A, Laurino M, et al: How breath-control can change your life: a systematic review on psycho-physiological correlates of slow breathing. Front Hum Neurosci 2018; 12:353
51. Meuret AE, Kroll J, Ritz T: Panic disorder comorbidity with medical conditions and treatment implications. Annu Rev Clin Psychol 2017; 13:209-240
52. Ley R: The modification of breathing behavior. Pavlovian and operant control in emotion and cognition. Behav Modif 1999; 23:441-479
53. Conrad A, Müller A, Doberenz S, et al: Psychophysiological effects of breathing instructions for stress management. Appl Psychophysiol Biofeedback 2007; 32:89-98
54. Gerber M, Jonsdottir IH, Lindwall M, et al: Physical activity in employees with differing occupational stress and mental health profiles: a latent profile analysis. Psychol Sport Exerc 2014; 15:649-658
55. Rosenbaum S, Tiedemann A, Sherrington C, et al: Physical activity interventions for people with mental illness: a systematic review and meta-analysis. J Clin Psychiatry 2014; 75:964-974
56. Schuch FB, Vancampfort D, Richards J, et al: Exercise as a treatment for depression: a meta-analysis adjusting for publication bias. J Psychiatr Res 2018; 77:42-51
57. Gordon BR, McDowell CP, Hallgren M, et al: Association of efficacy of resistance exercise training with depressive symptoms: meta-analysis and meta-regression analysis of randomized clinical trials. JAMA Psychiatry 2018; 75:566-576
58. Walker M: Why We Sleep: Unlocking the Power of Sleep and Dreams. New York, Scribner, 2017
59. Baglioni C, Battagliese G, Feige B, et al: Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies. J Affect Disord 2011; 135:10-19
60. Freeman D, Sheaves B, Goodwin GM, et al: The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis. Lancet Psychiatry 2017; 4:749-758
61. Hirshkowitz M, Whiton K, Albert SM, et al: National Sleep Foundation's sleep time duration recommendations: methodology and results summary. Sleep Health 2015; 1:40-43
62. Chang SM, Chen CH: Effects of an intervention with drinking chamomile tea on sleep quality and depression in sleep disturbed postnatal women: a randomized controlled trial. J Adv Nurs 2016; 72:306-315
63. Ngan A, Conduit R: A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality. Phytother Res 2011; 25:1153-1159
64. Koulivand PH, Khaleghi Ghadiri M, Gorji A: Lavender and the nervous system. Evid Based Complement Alternat Med 2013; 2013:681304
65. Enshaieh S, Jooya A, Siadat AH, et al: The efficacy of 5% topical tea tree oil gel in mild to moderate acne vulgaris: a randomized, double-blind placebo-controlled study. Indian J Dermatol Venereol Leprol 2007; 73:22-25
66. Hwang JH, Gobble J: Lavender for anxiety in the perioperative setting. AORN J 2021; 114:8-19
67. López V, Nielsen B, Solas M, et al: Exploring pharmacological mechanisms of lavender (Lavandula angustifolia) essential oil on central nervous system targets. Front Pharmacol 2017; 8:280
68. Donelli D, Antonelli M, Bellinazzi C, et al: Effects of lavender on anxiety: a systematic review and meta-analysis. Phytomedicine 2019; 65:153099
69. Salamati A, Mashouf S, Mojab F: Effect of inhalation of lavender essential oil on vital signs in open heart surgery ICU. Iran J Pharm Res 2017; 16:404-409
70. Cho MY, Min ES, Hur MH, et al: Effects of aromatherapy on the anxiety, vital signs, and sleep quality of percutaneous coronary intervention patients in intensive care units. Evid Based Complement Alternat Med 2013; 2013:381381